The massive Global Burden Of Disease study conducted by the World Health Organization, the World Bank, and Harvard University measured the leading causes of disability (counting lost years of healthy life). In developed countries, the ten leading causes of lost years of healthy life at ages 15-44 were: (1) Major Depressive Disorder, (2) Alcohol Use, (3) Road Traffic Accidents, (4) Schizophrenia, (5) Self-Inflicted Injuries, (6) Bipolar Disorder, (7) Drug Use, (8) Obsessive-Compulsive Disorders, (9) Osteoarthritis, (10) Violence. "

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